Higenamine is a fat-burning molecule which functions as a beta-receptor agonist, thus stimulating Lipolysis and allowing your body to burn more fat for fuel.
In this regard, it may be synergistic with alpha-receptor antagonists, such as Rauwolscine.
Ideally, Higenamine should be taken just prior to exercise and, due to it's strong safety profile, it can be combined with pre-workouts which already contain Caffeine, such as Catalyst.
Since it is a stimulant, Higenamine will be most effective on an empty stomach and is a perfect option for enhancing the fat-burning effects of fasted training.
If you use Higenamine to increase fat-loss during exercise, you'll may also want to consider Amino Beyond to negate any muscle loss and perform better.